Nymalize is the liquid nimodipine you know and trust for your patients with SAH1,2,6,8,9

The only RTU liquid nimodipine offering multiple dosing and administration options1


American Society of Health-System Pharmacists guidelines recommend the use of ready-to-use medications whenever possible to reduce situations requiring manipulations and prevent errors10

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Nymalize has efficient and flexible RTU dosing options that include prefilled oral syringes, prefilled ENFit syringes, and bottles to meet the needs of patients, providers, and hospitals alike.1

About nimodipine: a trusted molecule since 19884


  • Nimodipine reduces the incidence and severity of brain function loss in patients with subarachnoid hemorrhage (SAH).1 Nimodipine was originally only available as liquid-filled gel capsules, but most stroke patients have difficulty swallowing capsules.3 Dysphagia is a common occurrence after stroke, happening in ≥65% of stroke patients11
  • Before Nymalize, the practice of extracting nimodipine from capsules was the only option3,9
  • If the capsule cannot be swallowed, the contents of the capsule are extracted into a syringe using a needle and administered via a nasogastric tube3

Timeline of Nimodipine Advancement


19884

Nimodipine oral capsule

20102

FDA issues safety communication warning against intravenous use of nimodipine oral capsules

201312

Discontinued 202012

202013

Nymalize

20241

NymalizeNymalize

NYMALIZE HAS BEEN REFORMULATED TO INCLUDE

Higher concentration (6 mg/mL) per dose1,14
50% reduction in liquid volume per dose1,14
44% less polyethylene glycol per 60 mg dose15,a

a6.6 grams polyethylene glycol/60 mg dose.

When it comes to extracting nimodipine, the chance for errors is high2


For the standard dose of 60 mg (2 x 30 mg capsules every 4 hours), liquid nimodipine must be extracted from 12 capsules per day3


  • Potential risk for needle sticks during the extraction process4
  • The pharmacy is required to prepare extracted liquid nimodipine in advance or forces the ICU nurse to perform a bedside extraction to ensure appropriate nimodipine treatment initiation per CSC quality metrics5,6
≈25%

There is a potential for ≈25% dose reduction with each 60 mg dose4

Capsule extraction is time-consuming and exposes patients to potentially lethal medication errors2,3

Pharmacy prepares extracted liquid nimodipine in advance

or

ICU nurse performs a bedside extraction

Capsule Extraction Methods5

Between 1989 and 2013, 36 nimodipine-related medication errors were reported; 27 of these were associated with erroneous IV administration, and 5 of these cases resulted in death.2

Reducing risk to patients is a priority, using Nymalize provides precision and may reduce dosing and administration inaccuracy1